{"id":15078,"date":"2022-06-14T20:42:45","date_gmt":"2022-06-14T20:42:45","guid":{"rendered":"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/"},"modified":"2023-02-17T20:01:00","modified_gmt":"2023-02-17T20:01:00","slug":"fenotipo-reversible-en-un-modelo-humanizado-en-ratones","status":"publish","type":"post","link":"https:\/\/dupmecp2.eu\/el\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/","title":{"rendered":"Fenotipo reversible en un modelo humanizado en ratones"},"content":{"rendered":"<p><strong>Shao et al. del grupo del Prof. Zoghbi (Baylor College of Medicine, Texas, EE.UU.) publicaron un art\u00edculo en Science Translational medicine titulado \" Terapia con oligonucle\u00f3tidos antisentido en un modelo humanizado del s\u00edndrome de duplicaci\u00f3n MECP2 en ratones\". <\/strong><\/p>\n\n<p><strong>\u039a\u03ac\u03b8\u03b5 \u03b5\u03af\u03b4\u03bf\u03c2 \u03ad\u03c7\u03b5\u03b9 \u03c4\u03b1 \u03b4\u03b9\u03ba\u03ac \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03bf\u03cd\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03ae\u03ba\u03bf\u03c5\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03b5\u03af\u03b4\u03bf\u03c2. \u0395\u03af\u03bd\u03b1\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc \u03bf\u03b9 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03b1\u03c1\u03bf\u03c5\u03c1\u03b1\u03af\u03bf\u03c5 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03bf\u03bb\u03cd \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2. \u03a4\u03bf \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c1\u03b3\u03b1\u03c3\u03af\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03c3\u03c4\u03b7\u03ba\u03b5, \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03c9\u03c2 \"\u03b1\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf\", \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03c3\u03b7\u03bc\u03b9\u03ba\u03ce\u03bd \u03bf\u03bb\u03b9\u03b3\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03b9\u03b4\u03af\u03c9\u03bd (ASO) \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03b7 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c0\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1\u03bd \u03b1\u03c1\u03bf\u03c5\u03c1\u03b1\u03af\u03bf. Por lo tanto, est\u00e1 m\u00e1s cerca del futuro uso de ASO en humanos.<\/strong><\/p>\n\n<p><strong>Este art\u00edculo presenta los resultados obtenidos tras la inyecci\u00f3n intracerebroventricular de oligonucle\u00f3tidos antisentido en un modelo de duplicaci\u00f3n g\u00e9nica \" MECP2 humanizado \" en el que el rat\u00f3n porta dos alelos MECP2 humanos y ning\u00fan alelo end\u00f3geno.<\/strong><\/p>\n\n<p><strong>\u0397 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 MECP2 \u03c3\u03b5 \u03cc\u03bb\u03bf \u03c4\u03bf\u03bd \u03b5\u03b3\u03ba\u03ad\u03c6\u03b1\u03bb\u03bf \u03c4\u03c9\u03bd \u03b1\u03c1\u03bf\u03c5\u03c1\u03b1\u03af\u03c9\u03bd, \u03b5\u03be\u03ac\u03bb\u03b5\u03b9\u03c8\u03b5 \u03c0\u03bf\u03b9\u03ba\u03af\u03bb\u03b5\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03ac\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ad\u03c3\u03c4\u03b7\u03c3\u03b5 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf MeCP2 \u03c3\u03b5 \u03bc\u03bf\u03c1\u03c6\u03ae \u03b4\u03bf\u03c3\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1.<\/strong><\/p>\n\n<p>\u0398\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03bf\u03bb\u03b9\u03b3\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03b1 \u03b1\u03bd\u03c4\u03b9-\u03b1\u03bd\u03c4\u03b9-\u03c3\u03c5\u03bd\u03b5\u03af\u03b4\u03b7\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03b5\u03be\u03b1\u03bd\u03b8\u03c1\u03c9\u03c0\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf \u03c0\u03bf\u03bd\u03c4\u03b9\u03ba\u03bf\u03cd \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03bf\u03cd \u03c4\u03bf\u03c5 MECP2, Shao et al.<em>Sci. Transl. Med<\/em>. <strong>13<\/strong>, 7785 (2021)<\/p>\n\n<p><\/p>\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n<p><\/p>\n\n<p><strong>\u03a0\u0395\u03a1\u038a\u039b\u0397\u03a8\u0397 \u03a4\u0397\u03a3 \u0394\u0397\u039c\u039f\u03a3\u038a\u0395\u03a5\u03a3\u0397\u03a3<\/strong><\/p>\n\n<p>\u03a0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03bd\u03bf\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03b1\u03c0\u03b7\u03c1\u03af\u03b1\u03c2 \u03bf\u03c6\u03b5\u03af\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03c3\u03c4\u03bf\u03bd \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03c4\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03b3\u03c1\u03ac\u03c6\u03c9\u03bd \u03ba\u03b1\u03b9 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2 \u03b3\u03b9\u03b1 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b1 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ce\u03bd. El s\u00edndrome de duplicaci\u00f3n MECP2 (MDS) es uno de los reordenamientos gen\u00f3micos m\u00e1s comunes en varones y resulta de duplicaciones que abarcan el locus del gen de la prote\u00edna de uni\u00f3n metil-CpG 2 (MECP2). Anteriormente demostramos que la terapia con oligonucle\u00f3tidos antisentido (ASO) puede reducir la cantidad de prote\u00edna MeCP2 en modelo en ratones con MDS y revertir las caracter\u00edsticas de la enfermedad.<\/p>\n\n<p>Este modelo en ratones con MDS, sin embargo, presentaba un alelo humano transg\u00e9nico y un alelo de rat\u00f3n, estando este \u00faltimo protegido de la terapia MECP2-ASO espec\u00edfica para humanos.<\/p>\n\n<p>\u0395\u03c0\u03b5\u03b9\u03b4\u03ae \u03b7 MeCP2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03b5\u03c5\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03b7 \u03c3\u03c4\u03b7 \u03b4\u03cc\u03c3\u03b7, \u03b7 ASO \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03c4\u03b9\u03c4\u03bb\u03bf\u03b4\u03bf\u03c4\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03ad\u03c4\u03bf\u03b9\u03bf \u03c4\u03c1\u03cc\u03c0\u03bf \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03bc\u03b7\u03bd \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c5\u03c0\u03b5\u03c1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ac \u03c4\u03bf \u03ba\u03b1\u03bd\u03c4\u03b9\u03bd\u03c4\u03ac\u03bd\u03c4 \u03c4\u03b7\u03c2 MeCP2, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03c3\u03b5 \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf Rett. Por lo tanto, generamos un modelo de MDS \" MECP2 humanizado \" que porta dos alelos MECP2 humanos y ning\u00fan alelo end\u00f3geno de rat\u00f3n. \u0397 \u03b5\u03bd\u03b4\u03bf\u03b5\u03b3\u03ba\u03b5\u03c6\u03b1\u03bb\u03bf\u03ba\u03bf\u03b9\u03bb\u03b9\u03b1\u03ba\u03ae \u03ad\u03b3\u03c7\u03c5\u03c3\u03b7 \u03c4\u03bf\u03c5 MECP2-ASO \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b5 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 MECP2 \u03c3\u03c4\u03bf\u03bd \u03b5\u03b3\u03ba\u03ad\u03c6\u03b1\u03bb\u03bf \u03b1\u03c5\u03c4\u03ce\u03bd \u03c4\u03c9\u03bd \u03b1\u03c1\u03bf\u03c5\u03c1\u03b1\u03af\u03c9\u03bd. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03c4\u03bf MECP2-ASO \u03bc\u03b5\u03c4\u03c1\u03af\u03b1\u03c3\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b1 \u03b5\u03bb\u03bb\u03b5\u03af\u03bc\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03ac\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ad\u03c3\u03c4\u03b7\u03c3\u03b5 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03c9\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf MECP2 \u03bc\u03b5 \u03b4\u03bf\u03c3\u03bf\u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bc\u03b5\u03bd\u03bf \u03c4\u03c1\u03cc\u03c0\u03bf \u03c7\u03c9\u03c1\u03af\u03c2 \u03ba\u03b1\u03bc\u03af\u03b1 \u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1. La administraci\u00f3n de MECP2-ASO en el sistema nervioso central es, por tanto, bien tolerada y beneficiosa en este modelo de rat\u00f3n y proporciona un enfoque traducible que podr\u00eda ser factible para el tratamiento de los MDS.<\/p>\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill\"><a class=\"wp-block-button__link has-background wp-element-button\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33658357\/\" style=\"border-radius:14px;background-color:#f7a13f\" target=\"_blank\" rel=\"noreferrer noopener\">Ver la publicaci\u00f3n<\/a><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Shao et al. del grupo del Prof. Zoghbi (Baylor College of Medicine, Texas, EE.UU.) publicaron un art\u00edculo en Science Translational medicine titulado \u00a0\u00bb Terapia con oligonucle\u00f3tidos antisentido en un modelo [&hellip;]<\/p>","protected":false},"author":1,"featured_media":13608,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[113],"tags":[],"class_list":["post-15078","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publicacion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Fenotipo reversible en un modelo humanizado en ratones - DupMECP2<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dupmecp2.eu\/el\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es\" \/>\n<meta property=\"og:locale\" content=\"el_GR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fenotipo reversible en un modelo humanizado en ratones - DupMECP2\" \/>\n<meta property=\"og:description\" content=\"Shao et al. del grupo del Prof. Zoghbi (Baylor College of Medicine, Texas, EE.UU.) publicaron un art\u00edculo en Science Translational medicine titulado \u00a0\u00bb Terapia con oligonucle\u00f3tidos antisentido en un modelo [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dupmecp2.eu\/el\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es\" \/>\n<meta property=\"og:site_name\" content=\"DupMECP2\" \/>\n<meta property=\"article:published_time\" content=\"2022-06-14T20:42:45+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-02-17T20:01:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Publication-Zoghbi-Souris-Humanisees.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1500\" \/>\n\t<meta property=\"og:image:height\" content=\"1050\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Caroline\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u03a3\u03c5\u03bd\u03c4\u03ac\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc\" \/>\n\t<meta name=\"twitter:data1\" content=\"Caroline\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u0395\u03ba\u03c4\u03b9\u03bc\u03ce\u03bc\u03b5\u03bd\u03bf\u03c2 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 \u03bb\u03b5\u03c0\u03c4\u03ac\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es#article\",\"isPartOf\":{\"@id\":\"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es\"},\"author\":{\"name\":\"Caroline\",\"@id\":\"https:\/\/dupmecp2.eu\/#\/schema\/person\/b41e8cbba153cd974ee340386af279ee\"},\"headline\":\"Fenotipo reversible en un modelo humanizado en ratones\",\"datePublished\":\"2022-06-14T20:42:45+00:00\",\"dateModified\":\"2023-02-17T20:01:00+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es\"},\"wordCount\":534,\"publisher\":{\"@id\":\"https:\/\/dupmecp2.eu\/#organization\"},\"image\":{\"@id\":\"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Publication-Zoghbi-Souris-Humanisees.jpg\",\"articleSection\":[\"Publicaci\u00f3n\"],\"inLanguage\":\"el\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es\",\"url\":\"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es\",\"name\":\"Fenotipo reversible en un modelo humanizado en ratones - DupMECP2\",\"isPartOf\":{\"@id\":\"https:\/\/dupmecp2.eu\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es#primaryimage\"},\"image\":{\"@id\":\"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Publication-Zoghbi-Souris-Humanisees.jpg\",\"datePublished\":\"2022-06-14T20:42:45+00:00\",\"dateModified\":\"2023-02-17T20:01:00+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es#breadcrumb\"},\"inLanguage\":\"el\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"el\",\"@id\":\"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es#primaryimage\",\"url\":\"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Publication-Zoghbi-Souris-Humanisees.jpg\",\"contentUrl\":\"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Publication-Zoghbi-Souris-Humanisees.jpg\",\"width\":1500,\"height\":1050},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/dupmecp2.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publicaci\u00f3n\",\"item\":\"https:\/\/dupmecp2.eu\/category\/publicacion\/?lang=es\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Fenotipo reversible en un modelo humanizado en ratones\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/dupmecp2.eu\/#website\",\"url\":\"https:\/\/dupmecp2.eu\/\",\"name\":\"DupMECP2\",\"description\":\"EU\",\"publisher\":{\"@id\":\"https:\/\/dupmecp2.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/dupmecp2.eu\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"el\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/dupmecp2.eu\/#organization\",\"name\":\"DupMECP2\",\"url\":\"https:\/\/dupmecp2.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"el\",\"@id\":\"https:\/\/dupmecp2.eu\/#\/schema\/logo\/image\/\",\"url\":\"\",\"contentUrl\":\"\",\"caption\":\"DupMECP2\"},\"image\":{\"@id\":\"https:\/\/dupmecp2.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/dupmecp2.eu\/#\/schema\/person\/b41e8cbba153cd974ee340386af279ee\",\"name\":\"Caroline\",\"sameAs\":[\"https:\/\/dupmecp2.eu\"],\"url\":\"https:\/\/dupmecp2.eu\/el\/author\/417a2385dc37aa45\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Fenotipo reversible en un modelo humanizado en ratones - DupMECP2","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/dupmecp2.eu\/el\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es","og_locale":"el_GR","og_type":"article","og_title":"Fenotipo reversible en un modelo humanizado en ratones - DupMECP2","og_description":"Shao et al. del grupo del Prof. Zoghbi (Baylor College of Medicine, Texas, EE.UU.) publicaron un art\u00edculo en Science Translational medicine titulado \u00a0\u00bb Terapia con oligonucle\u00f3tidos antisentido en un modelo [&hellip;]","og_url":"https:\/\/dupmecp2.eu\/el\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es","og_site_name":"DupMECP2","article_published_time":"2022-06-14T20:42:45+00:00","article_modified_time":"2023-02-17T20:01:00+00:00","og_image":[{"width":1500,"height":1050,"url":"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Publication-Zoghbi-Souris-Humanisees.jpg","type":"image\/jpeg"}],"author":"Caroline","twitter_card":"summary_large_image","twitter_misc":{"\u03a3\u03c5\u03bd\u03c4\u03ac\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc":"Caroline","\u0395\u03ba\u03c4\u03b9\u03bc\u03ce\u03bc\u03b5\u03bd\u03bf\u03c2 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2":"3 \u03bb\u03b5\u03c0\u03c4\u03ac"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es#article","isPartOf":{"@id":"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es"},"author":{"name":"Caroline","@id":"https:\/\/dupmecp2.eu\/#\/schema\/person\/b41e8cbba153cd974ee340386af279ee"},"headline":"Fenotipo reversible en un modelo humanizado en ratones","datePublished":"2022-06-14T20:42:45+00:00","dateModified":"2023-02-17T20:01:00+00:00","mainEntityOfPage":{"@id":"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es"},"wordCount":534,"publisher":{"@id":"https:\/\/dupmecp2.eu\/#organization"},"image":{"@id":"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es#primaryimage"},"thumbnailUrl":"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Publication-Zoghbi-Souris-Humanisees.jpg","articleSection":["Publicaci\u00f3n"],"inLanguage":"el"},{"@type":"WebPage","@id":"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es","url":"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es","name":"Fenotipo reversible en un modelo humanizado en ratones - DupMECP2","isPartOf":{"@id":"https:\/\/dupmecp2.eu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es#primaryimage"},"image":{"@id":"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es#primaryimage"},"thumbnailUrl":"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Publication-Zoghbi-Souris-Humanisees.jpg","datePublished":"2022-06-14T20:42:45+00:00","dateModified":"2023-02-17T20:01:00+00:00","breadcrumb":{"@id":"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es#breadcrumb"},"inLanguage":"el","potentialAction":[{"@type":"ReadAction","target":["https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es"]}]},{"@type":"ImageObject","inLanguage":"el","@id":"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es#primaryimage","url":"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Publication-Zoghbi-Souris-Humanisees.jpg","contentUrl":"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Publication-Zoghbi-Souris-Humanisees.jpg","width":1500,"height":1050},{"@type":"BreadcrumbList","@id":"https:\/\/dupmecp2.eu\/fenotipo-reversible-en-un-modelo-humanizado-en-ratones\/?lang=es#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/dupmecp2.eu\/"},{"@type":"ListItem","position":2,"name":"Publicaci\u00f3n","item":"https:\/\/dupmecp2.eu\/category\/publicacion\/?lang=es"},{"@type":"ListItem","position":3,"name":"Fenotipo reversible en un modelo humanizado en ratones"}]},{"@type":"WebSite","@id":"https:\/\/dupmecp2.eu\/#website","url":"https:\/\/dupmecp2.eu\/","name":"DupMECP2","description":"\u0395\u0395","publisher":{"@id":"https:\/\/dupmecp2.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/dupmecp2.eu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"el"},{"@type":"Organization","@id":"https:\/\/dupmecp2.eu\/#organization","name":"DupMECP2","url":"https:\/\/dupmecp2.eu\/","logo":{"@type":"ImageObject","inLanguage":"el","@id":"https:\/\/dupmecp2.eu\/#\/schema\/logo\/image\/","url":"","contentUrl":"","caption":"DupMECP2"},"image":{"@id":"https:\/\/dupmecp2.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/dupmecp2.eu\/#\/schema\/person\/b41e8cbba153cd974ee340386af279ee","name":"\u039a\u03b1\u03c1\u03bf\u03bb\u03af\u03bd\u03b1","sameAs":["https:\/\/dupmecp2.eu"],"url":"https:\/\/dupmecp2.eu\/el\/author\/417a2385dc37aa45\/"}]}},"_links":{"self":[{"href":"https:\/\/dupmecp2.eu\/el\/wp-json\/wp\/v2\/posts\/15078","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dupmecp2.eu\/el\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dupmecp2.eu\/el\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dupmecp2.eu\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dupmecp2.eu\/el\/wp-json\/wp\/v2\/comments?post=15078"}],"version-history":[{"count":0,"href":"https:\/\/dupmecp2.eu\/el\/wp-json\/wp\/v2\/posts\/15078\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dupmecp2.eu\/el\/wp-json\/wp\/v2\/media\/13608"}],"wp:attachment":[{"href":"https:\/\/dupmecp2.eu\/el\/wp-json\/wp\/v2\/media?parent=15078"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dupmecp2.eu\/el\/wp-json\/wp\/v2\/categories?post=15078"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dupmecp2.eu\/el\/wp-json\/wp\/v2\/tags?post=15078"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}