{"id":27573,"date":"2024-08-29T17:24:40","date_gmt":"2024-08-29T15:24:40","guid":{"rendered":"https:\/\/dupmecp2.eu\/?p=27573"},"modified":"2025-07-23T10:41:12","modified_gmt":"2025-07-23T08:41:12","slug":"ion440-2","status":"publish","type":"post","link":"https:\/\/dupmecp2.eu\/el\/ion440-2\/","title":{"rendered":"ION440: \u0397 IONIS \u03c0\u03b7\u03b3\u03b1\u03af\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03bf\u03b9\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 MDS \u03c3\u03c4\u03bf \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bfION440: \u0397 IONIS \u03c0\u03b7\u03b3\u03b1\u03af\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03bf\u03b9\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 MDS \u03c3\u03c4\u03bf \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf"},"content":{"rendered":"<p>\u0393\u03c1\u03ac\u03c6\u03c4\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd David \u03ba\u03b1\u03b9 \u03b5\u03bb\u03ad\u03b3\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd Ionis<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u03a3\u03b5 \u03c3\u03c5\u03bd\u03ad\u03c7\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7\u03c2 \u03b1\u03bd\u03b1\u03ba\u03bf\u03af\u03bd\u03c9\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 Ionis \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03ba\u03b5\u03af\u03bc\u03b5\u03bd\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae, \u03b8\u03b1 \u03b8\u03ad\u03bb\u03b1\u03bc\u03b5 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ac\u03c3\u03c7\u03bf\u03c5\u03bc\u03b5 \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b5\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae. \u0395\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03ba\u03ad\u03c6\u03c4\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03b3\u03b3\u03c1\u03ac\u03c8\u03bf\u03c5\u03bd \u03c4\u03bf \u03c0\u03b1\u03b9\u03b4\u03af \u03c4\u03bf\u03c5\u03c2 \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03bd\u03b1 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae, \u03b9\u03b4\u03af\u03c9\u03c2 \u03c3\u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03c3\u03c0\u03ac\u03bd\u03b9\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03b9\u03ce\u03bd \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03bf\u03cd \u03c4\u03bf\u03c5 MECP2 (MDS).  <\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u0397 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae (\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae) \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b5\u03af\u03b4\u03bf\u03c2 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03bc\u03b5\u03bb\u03b5\u03c4\u03ac \u03bd\u03ad\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af \u03c4\u03b7\u03bd \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf. \u039f\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03bf\u03cd\u03bd \u03c3\u03c5\u03c7\u03bd\u03ac \u03bc\u03ad\u03c1\u03bf\u03c2 \u03b5\u03bd\u03cc\u03c2 \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03bf\u03c5 \u03c0\u03c1\u03bf\u03b3\u03c1\u03ac\u03bc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2. \u0388\u03bd\u03b1 \u03c0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c3\u03b5\u03b9\u03c1\u03ac \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b5\u03be\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03c1\u03bf\u03bf\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c6\u03ac\u03c3\u03b5\u03b9\u03c2 (\u03b4\u03b7\u03bb. \u03b1\u03c0\u03cc \u03c4\u03b7 \u03c6\u03ac\u03c3\u03b7 1 \u03ad\u03c9\u03c2 \u03c4\u03b7 \u03c6\u03ac\u03c3\u03b7 3) \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03c9\u03b8\u03b5\u03af \u03b5\u03ac\u03bd \u03c4\u03b1 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ac \u03bd\u03ad\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03b1\u03c1\u03ba\u03ce\u03c2 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ae \u03ba\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac.  <\/p>\n\n\n\n<p>\u03a3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 MDS, \u03b7 Ionis \u03b8\u03b1 \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03b5\u03b9 \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03bc\u03b9\u03b1\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ae\u03c2 \u03bd\u03ad\u03b1\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bf\u03bd\u03bf\u03bc\u03b1\u03c3\u03af\u03b1 ION440. \u0397 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 ATTUNE \u03b1\u03bd\u03b1\u03ba\u03bf\u03b9\u03bd\u03ce\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd Ionis \u03c3\u03c4\u03bf clinicaltrials.gov \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03bc\u03bf \u03c4\u03af\u03c4\u03bb\u03bf \u03c4\u03b7\u03c2 \"A Phase 1-2, Double-Blind, Sham-Controlled Multiple Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Patients With MECP2 Duplication Syndrome\". <\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u0391\u03c2 \u03b1\u03c0\u03bf\u03ba\u03c1\u03c5\u03c0\u03c4\u03bf\u03b3\u03c1\u03b1\u03c6\u03ae\u03c3\u03bf\u03c5\u03bc\u03b5 \u03c4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c5\u03c4\u03cc.<\/p>\n\n\n\n<p><strong>\u0394\u03bf\u03ba\u03b9\u03bc\u03ae \u03c6\u03ac\u03c3\u03b7\u03c2 1-2 :<\/strong> \u0397 \u03a6\u03ac\u03c3\u03b7 1 \u03b1\u03bd\u03c4\u03b9\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b5\u03cd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03c6\u03bf\u03c1\u03ac \u03c0\u03bf\u03c5 \u03ad\u03bd\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c7\u03bf\u03c1\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 (\u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \"first-in-human\"). \u0397 \u03a6\u03ac\u03c3\u03b7 1 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03c4\u03b5\u03af \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c0\u03c1\u03bf\u03c3\u03b4\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc \u03c4\u03b7\u03c2 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03cc \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2- \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b9\u03ba\u03ac \u03bc\u03b9\u03ba\u03c1\u03ae \u03ba\u03b1\u03b9 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03b7. \u039f\u03b9 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 2 \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03b1\u03b9\u03c4\u03ad\u03c1\u03c9 \u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1, \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bd\u03ad\u03bf\u03c5 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03b1\u03c1\u03b9\u03b8\u03bc\u03cc \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03b3\u03b9\u03b1 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1. \u03a3\u03c5\u03c7\u03bd\u03ac, \u03c3\u03c4\u03b9\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 2, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 ATTUNE, \u03bf\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b9\u03ce\u03ba\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03ae\u03c3\u03bf\u03c5\u03bd \u03c0\u03ce\u03c2 \u03bf\u03b9 \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf\u03b9 \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03b5\u03b9\u03c1\u03b1\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5. \u0397 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae ATTUNE \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd \u03c6\u03ac\u03c3\u03b7\u03c2 1 \u03ba\u03b1\u03b9 \u03c6\u03ac\u03c3\u03b7\u03c2 2.    <\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>\u03a4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7, \u03b4\u03b9\u03c0\u03bb\u03ac \u03c4\u03c5\u03c6\u03bb\u03ae, \u03b5\u03bb\u03b5\u03b3\u03c7\u03cc\u03bc\u03b5\u03bd\u03b7 \u03bc\u03b5 \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03cc \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf:<\/strong> \u0391\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03bd\u03c4\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ad\u03bc\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03c5\u03c7\u03b1\u03af\u03b1 \u03bd\u03b1 \u03bb\u03ac\u03b2\u03bf\u03c5\u03bd \u03b5\u03af\u03c4\u03b5 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 ION440 \u03b5\u03af\u03c4\u03b5 \u03bc\u03b9\u03b1 \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (\u03c7\u03c9\u03c1\u03af\u03c2 \u03ad\u03bd\u03b5\u03c3\u03b7 \u03b1\u03bb\u03bb\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2) \u03c3\u03b5 \u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03af\u03b1 3:1 (3 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd ION440 \u03c0\u03c1\u03bf\u03c2 1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf). \u039f\u03cd\u03c4\u03b5 \u03bf\u03b9 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03bd\u03c4\u03b5\u03c2 \u03bf\u03cd\u03c4\u03b5 \u03bf\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03b3\u03bd\u03ce\u03c1\u03b9\u03b6\u03b1\u03bd \u03c0\u03bf\u03b9\u03bf\u03c2 \u03bb\u03ac\u03bc\u03b2\u03b1\u03bd\u03b5 \u03c4\u03b7\u03bd \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03b9\u03bf\u03c2 \u03c4\u03b7\u03bd \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03ae.  <\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u039c\u03b9\u03b1 \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 (\u03b5\u03b4\u03ce \u03b7 \"\u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03ae\" \u03bf\u03bc\u03ac\u03b4\u03b1) \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03cc\u03c4\u03b1\u03bd (1) \u03c4\u03b1 \u03c3\u03b7\u03bc\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03c4\u03bf \u03ad\u03bd\u03b1 \u03ac\u03c4\u03bf\u03bc\u03bf \u03c3\u03c4\u03bf \u03ac\u03bb\u03bb\u03bf (2) \u03b7 \u03c6\u03c5\u03c3\u03b9\u03ba\u03ae \u03b9\u03c3\u03c4\u03bf\u03c1\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03bf\u03cd \u03c4\u03b7\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 (3) \u03bf\u03b9 \u03c3\u03c4\u03cc\u03c7\u03bf\u03b9 \u03c4\u03b7\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bf\u03c1\u03b9\u03c3\u03c4\u03bf\u03cd\u03bd \u03bc\u03b5 \u03c4\u03c1\u03cc\u03c0\u03bf \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03b8\u03b5\u03c9\u03c1\u03b7\u03b8\u03b5\u03af \u03c5\u03c0\u03bf\u03ba\u03b5\u03b9\u03bc\u03b5\u03bd\u03b9\u03ba\u03cc\u03c2 \u03ae \u03bd\u03b1 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b5\u03af \u03bc\u03b5\u03c1\u03bf\u03bb\u03b7\u03c8\u03af\u03b1 \u03ba\u03b1\u03b9 (4) \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03cc\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c4\u03c1\u03cc\u03c0\u03bf\u03c5 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03bf\u03c0\u03bf\u03af\u03bf \u03bf \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03c0\u03c1\u03bf\u03c3\u03bb\u03b7\u03c6\u03b8\u03b5\u03af \u03b8\u03b1 \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03b9\u03b8\u03b5\u03af \u03c3\u03b5 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5\u03c2 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03b9\u03ce\u03bd, \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03ba\u03b1\u03b9 \u03b7 \u03bf\u03c3\u03c6\u03c5\u03bf\u03bd\u03c9\u03c4\u03b9\u03b1\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03ad\u03bd\u03c4\u03b7\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 ION440, \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>\u03a0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ae \u03b1\u03cd\u03be\u03bf\u03c5\u03c3\u03b1 \u03b4\u03cc\u03c3\u03b7 (MAD) :<\/strong> \u0391\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bd \u03b1\u03c5\u03be\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03b5\u03c7\u03cc\u03bd\u03c4\u03c9\u03bd, \u03c0\u03c1\u03bf\u03ba\u03b5\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5 \u03bd\u03b1 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03c3\u03bf\u03c5\u03bd \u03c0\u03cc\u03c3\u03b7 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03b7\u03b8\u03b5\u03af \u03bc\u03b5 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>\u039c\u03ad\u03c1\u03bf\u03c2 1 \u03ba\u03b1\u03b9 \u03bc\u03ad\u03c1\u03bf\u03c2 2 \u03c4\u03bf\u03c5 \u03c4\u03b5\u03c3\u03c4 :<\/strong> \u03a4\u03bf ATTUNE \u03c7\u03c9\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03cd\u03bf \u03bc\u03ad\u03c1\u03b7. \u038c\u03c3\u03bf\u03b9 \u03b3\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03bf\u03af \u03c3\u03c4\u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03b8\u03b1 \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03bf\u03c5\u03bd \u03bc\u03b5 \u03c4\u03bf \u03bc\u03ad\u03c1\u03bf\u03c2 1.<br>\u03a3\u03c4\u03bf \u03c0\u03c1\u03ce\u03c4\u03bf \u03bc\u03ad\u03c1\u03bf\u03c2, 75 % \u03c4\u03c9\u03bd \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03b5\u03c7\u03cc\u03bd\u03c4\u03c9\u03bd \u03b8\u03b1 \u03bb\u03ac\u03b2\u03bf\u03c5\u03bd ION440 \u03ba\u03b1\u03b9 25 % \u03b8\u03b1 \u03bb\u03ac\u03b2\u03bf\u03c5\u03bd \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 36 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2. \u039c\u03cc\u03bb\u03b9\u03c2 \u03b7 Ionis \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03ce\u03c3\u03b5\u03b9 \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03ce\u03c2 \u03c4\u03b7\u03bd \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2 \u03c3\u03c4\u03bf \u03c0\u03c1\u03ce\u03c4\u03bf \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae\u03c2, \u03bf\u03b9 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03ce\u03c3\u03b5\u03b9 \u03c4\u03bf \u03c0\u03c1\u03ce\u03c4\u03bf \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae\u03c2 \u03b8\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03c5\u03ba\u03b1\u03b9\u03c1\u03af\u03b1 \u03bd\u03b1 \u03bb\u03ac\u03b2\u03bf\u03c5\u03bd \u03c4\u03bf ION440 \u03b3\u03b9\u03b1 156 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03c3\u03c4\u03b7 \u03c6\u03ac\u03c3\u03b7 \u03b5\u03c0\u03ad\u03ba\u03c4\u03b1\u03c3\u03b7\u03c2 (LTE), \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03c9\u03c2 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03bf \u03bc\u03ad\u03c1\u03bf\u03c2.   <\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>\u0391\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1, \u03b1\u03bd\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1, \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae, \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03ae :<\/strong> \u03a4\u03b1 \u03ba\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03b1\u03c5\u03c4\u03ac \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c5\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 1-2 \u03b3\u03b9\u03b1 \u03c4\u03bf ION440, \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03b5\u03ac\u03bd \u03ae \u03c0\u03bf\u03b9\u03b5\u03c2 \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03bf\u03cd\u03bd \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 ION440, \u03c4\u03b9 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03bf \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c3\u03c4\u03bf ION440 \u03ba\u03b1\u03b9 \u03c4\u03b9 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf ION440 \u03c3\u03c4\u03bf\u03bd \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03bf \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>\u039a\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03ad\u03bd\u03c4\u03b1\u03be\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03bf\u03cd : <\/strong>\u039f\u03b9 \u03ba\u03b1\u03bd\u03cc\u03bd\u03b5\u03c2 \u03b1\u03c5\u03c4\u03bf\u03af \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c0\u03bf\u03b9\u03bf\u03b9 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03bb\u03ac\u03b2\u03bf\u03c5\u03bd \u03bc\u03ad\u03c1\u03bf\u03c2 \u03c3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae. \u0393\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1, \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae, \u03bf\u03b9 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2, \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd 2 \u03ba\u03b1\u03b9 65 \u03b5\u03c4\u03ce\u03bd, \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03bf\u03cd \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 MECP2 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b5 \u03b8\u03ad\u03c3\u03b7 \u03bd\u03b1 \u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03ae\u03c3\u03bf\u03c5\u03bd \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b5\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2. \u039f\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03b5\u03bc\u03c0\u03bf\u03b4\u03af\u03b6\u03bf\u03c5\u03bd \u03ad\u03bd\u03b1 \u03ac\u03c4\u03bf\u03bc\u03bf \u03bd\u03b1 \u03bb\u03ac\u03b2\u03b5\u03b9 \u03bc\u03ad\u03c1\u03bf\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c4\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5, \u03bd\u03b1 \u03c0\u03ac\u03c3\u03c7\u03b5\u03b9 \u03b1\u03c0\u03cc \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03c0\u03c1\u03bf\u03b2\u03bb\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c5\u03b3\u03b5\u03af\u03b1\u03c2 \u03ae \u03bd\u03b1 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1.  <\/p>\n\n\n\n<p>\u0395\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03b7 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03b8\u03b5\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c3\u03cd\u03c1\u03bf\u03c5\u03bd \u03b1\u03bd\u03ac \u03c0\u03ac\u03c3\u03b1 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae \u03b5\u03ac\u03bd \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd \u03cc\u03c4\u03b9 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03bf \u03c3\u03c5\u03bc\u03c6\u03ad\u03c1\u03bf\u03bd \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b9\u03b4\u03b9\u03bf\u03cd \u03c4\u03bf\u03c5\u03c2.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>\u0388\u03bd\u03b1\u03c1\u03be\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 : <\/strong>\u0397 \u03b5\u03ba\u03c4\u03b9\u03bc\u03ce\u03bc\u03b5\u03bd\u03b7 \u03b7\u03bc\u03b5\u03c1\u03bf\u03bc\u03b7\u03bd\u03af\u03b1 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 ATTUNE \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u0391\u03cd\u03b3\u03bf\u03c5\u03c3\u03c4\u03bf\u03c2 \u03c4\u03bf\u03c5 2024. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03c4\u03bf \u03c7\u03c1\u03bf\u03bd\u03bf\u03b4\u03b9\u03ac\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03b1\u03c5\u03c4\u03cc \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b1 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03bf\u03c1\u03cc\u03c3\u03b7\u03bc\u03b1, \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03b4\u03b5\u03bf\u03bd\u03c4\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2, \u03b7 \u03c5\u03c0\u03bf\u03b3\u03c1\u03b1\u03c6\u03ae \u03c3\u03cd\u03bc\u03b2\u03b1\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03b3\u03ba\u03c1\u03af\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf \u03cc\u03c0\u03bf\u03c5 \u03b8\u03b1 \u03b4\u03b9\u03b5\u03be\u03b1\u03c7\u03b8\u03b5\u03af \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7. \u0397 \u03b5\u03b3\u03b3\u03c1\u03b1\u03c6\u03ae \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03b8\u03b1 \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03b5\u03b9 \u03bc\u03cc\u03bb\u03b9\u03c2 \u03c5\u03c0\u03bf\u03b3\u03c1\u03b1\u03c6\u03bf\u03cd\u03bd \u03cc\u03bb\u03b5\u03c2 \u03bf\u03b9 \u03b5\u03b3\u03ba\u03c1\u03af\u03c3\u03b5\u03b9\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd Ionis \u03ba\u03b1\u03b9 \u03c4\u03bf \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>\u039c\u03b7\u03bd \u03be\u03b5\u03c7\u03bd\u03ac\u03c4\u03b5 \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bf\u03b4\u03bf \u03c4\u03b7\u03c2 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b3\u03bd\u03ce\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03be\u03b5\u03cd\u03c1\u03b5\u03c3\u03b7 \u03bd\u03ad\u03c9\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd \u03ba\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03b4\u03af\u03bd\u03bf\u03c5\u03bd \u03b5\u03bb\u03c0\u03af\u03b4\u03b1 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03ac\u03c3\u03c7\u03bf\u03c5\u03bd \u03b1\u03c0\u03cc \u03c3\u03c0\u03ac\u03bd\u03b9\u03b5\u03c2 \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2.<\/p>\n\n\n\n<p>\u03a4\u03bf ION440 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b5\u03b3\u03ba\u03c1\u03b9\u03b8\u03b5\u03af \u03b3\u03b9\u03b1 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03c9\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03bf\u03c0\u03bf\u03b9\u03b1\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c1\u03cc\u03bc\u03bf\u03c5 \u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03bf\u03cd \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 MECP2, \u03c3\u03b5 \u03ba\u03b1\u03bc\u03af\u03b1 \u03c7\u03ce\u03c1\u03b1.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><strong>\u0391\u03c5\u03c4\u03ae \u03c4\u03b7 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae \u03b5\u03c4\u03bf\u03b9\u03bc\u03ac\u03b6\u03bf\u03c5\u03bc\u03b5 \u03ad\u03bd\u03b1 \u03bb\u03b5\u03c0\u03c4\u03bf\u03bc\u03b5\u03c1\u03ad\u03c2 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03c4\u03c5\u03b1\u03ba\u03cc \u03c3\u03b5\u03bc\u03b9\u03bd\u03ac\u03c1\u03b9\u03bf \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf ATTUNE. \u03a0\u03c1\u03bf\u03b2\u03bb\u03ad\u03c0\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03ae\u03c3\u03b5\u03b9 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c4\u03bf \u03c4\u03ad\u03bb\u03bf\u03c2 \u03a3\u03b5\u03c0\u03c4\u03b5\u03bc\u03b2\u03c1\u03af\u03bf\u03c5 2024. \u039c\u03b5\u03af\u03bd\u03b5\u03c4\u03b5 \u03c3\u03c5\u03bd\u03c4\u03bf\u03bd\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03b9 \ud83d\ude09<\/strong><\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-white-color has-text-color has-background wp-element-button\" href=\"https:\/\/clinicaltrials.gov\/study\/NCT06430385?cond=Mecp2%20Duplication%20Syndromerank=2\" style=\"border-radius:15px;background-color:#f7a13f\">\u03a3\u03c4\u03bf clinicaltrials.gov<\/a><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>\u00c9crit par David et v\u00e9rifi\u00e9 par Ionis Suite \u00e0 l&rsquo;annonce faite r\u00e9cemment par Ionis au sujet de l&rsquo;essai clinique \u00e0 venir, nous souhaitons apporter de plus amples informations sur cet [&hellip;]<\/p>","protected":false},"author":1,"featured_media":27567,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-27573","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualite"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>ION440 : IONIS fait passer la communaut\u00e9 MDS \u00e0 la vitesse sup\u00e9rieureION440 : IONIS propulse la communaut\u00e9 MDS \u00e0 un niveau sup\u00e9rieur - DupMECP2<\/title>\n<meta name=\"description\" content=\"Suite \u00e0 l&#039;annonce faite r\u00e9cemment par Ionis au sujet de l&#039;essai clinique 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Il est particuli\u00e8rement important pour les familles qui envisagent de faire participer leur enfant \u00e0 un essai clinique de savoir ce qu&#039;est un essai clinique, en particulier dans le contexte de maladies rares comme le syndrome de duplication du g\u00e8ne MECP2 (MDS).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dupmecp2.eu\/el\/ion440-2\/\" \/>\n<meta property=\"og:locale\" content=\"el_GR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"ION440 : IONIS fait passer la communaut\u00e9 MDS \u00e0 la vitesse sup\u00e9rieureION440 : IONIS propulse la communaut\u00e9 MDS \u00e0 un niveau sup\u00e9rieur - DupMECP2\" \/>\n<meta property=\"og:description\" content=\"Suite \u00e0 l&#039;annonce faite r\u00e9cemment par Ionis au sujet de l&#039;essai clinique \u00e0 venir, nous souhaitons apporter de plus amples informations sur cet essai. 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