{"id":7363,"date":"2022-06-14T20:42:45","date_gmt":"2022-06-14T18:42:45","guid":{"rendered":"http:\/\/carola.wwwnl1-sr12.supercp.com\/2022\/06\/14\/reversibler-phaenotyp-bei-maeusen\/"},"modified":"2022-11-13T13:19:33","modified_gmt":"2022-11-13T13:19:33","slug":"%ce%b1%ce%bd%ce%b1%cf%83%cf%84%cf%81%ce%b5%cf%86%cf%8c%ce%bc%ce%b5%ce%bd%ce%bf%cf%82-%cf%86%ce%b1%ce%bd%ce%bf%cf%84%cf%8d%cf%80%ce%bf%cf%82-%cf%83%ce%b5-maeusen","status":"publish","type":"post","link":"https:\/\/dupmecp2.eu\/el\/%ce%b1%ce%bd%ce%b1%cf%83%cf%84%cf%81%ce%b5%cf%86%cf%8c%ce%bc%ce%b5%ce%bd%ce%bf%cf%82-%cf%86%ce%b1%ce%bd%ce%bf%cf%84%cf%8d%cf%80%ce%bf%cf%82-%cf%83%ce%b5-maeusen\/","title":{"rendered":"Reversibler Ph\u00e4notyp bei M\u00e4usen"},"content":{"rendered":"<p><strong>\u039f \u03ba\u03b1\u03b8\u03b7\u03b3\u03b7\u03c4\u03ae\u03c2 Huda Zoghbi \u03ba.\u03ac. (Baylor College of Medicine, \u03a4\u03ad\u03be\u03b1\u03c2, \u0397\u03a0\u0391) \u03b4\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b1\u03bd \u03ad\u03bd\u03b1 \u03ac\u03c1\u03b8\u03c1\u03bf \u03c3\u03c4\u03b7\u03bd Zeitschrift Nature \u03bc\u03b5 \u03c4\u03af\u03c4\u03bb\u03bf \"Reversibler Ph\u00e4notyp bei M\u00e4usen durch die Verwendung von genetischer Rettung oder Antisense-Oligonukleotiden\". In diesem Artikel werden die Ergebnisse der Verwendung von Antisense-Oligonukleotiden (ASO) bei der Korrektur von MeCP2-Spiegeln und umgekehrt von Verhaltens-, molekularen und elektrophysiologischen St\u00f6rungen bei einem Tiermodell mit MeCP2-Genduplikation vorgestellt.<\/strong><\/p>\n\n\n\n<p>\u0391\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03c9\u03bd \u03c6\u03b1\u03b9\u03bd\u03bf\u03c4\u03cd\u03c0\u03c9\u03bd \u03c3\u03b5 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03bc\u03b5 \u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 MECP2 \u03bc\u03b5 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03ac\u03c3\u03c9\u03c3\u03b7\u03c2 \u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03b7\u03bc\u03b9\u03ba\u03ce\u03bd \u03bf\u03bb\u03b9\u03b3\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03b9\u03b4\u03af\u03c9\u03bd, Huda Zoghbi <em>et al,<\/em> <em>\u03a6\u03cd\u03c3\u03b7<\/em><strong> 528, <\/strong>123-126 (2015)<\/p>\n\n\n\n<p><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>ZUSAMMENFASSUNG DES ARTIKELS: (\u00dcbersetzt aus dem Englischen):<\/strong><\/p>\n\n\n\n<p>Eine Variation der Kopienanzahl wurde h\u00e4ufig mit Entwicklungsverz\u00f6gerungen, geistiger Behinderung und Autismus in Verbindung gebracht. \u03a4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf MECP2-Genduplikation \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ad\u03c2 \u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ad\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03c3\u03b5 \u03bd\u03ad\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc \u03c6\u03ac\u03c3\u03bc\u03b1, \u03c3\u03bf\u03b2\u03b1\u03c1\u03ae \u03b1\u03bd\u03b1\u03c0\u03b7\u03c1\u03af\u03b1, \u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1, \u03b1\u03b3\u03c7\u03ce\u03b4\u03b5\u03b9\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2, \u03b5\u03c0\u03b9\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03c1\u03af\u03c3\u03b5\u03b9\u03c2, \u03bc\u03bf\u03bb\u03cd\u03bd\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03cc\u03c9\u03c1\u03bf \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf.<\/p>\n\n\n\n<p>Die gro\u00dfe Vielfalt der Defizite, die durch die \u00dcberexpression des MeCP2-Proteins verursacht werden, stellt eine gro\u00dfe Herausforderung f\u00fcr herk\u00f6mmliche Therapieans\u00e4tze dar, die auf biochemischen Wegen beruhen. Daher haben wir therapeutische Strategies untersucht, die direkt auf das MeCP2-Protein abzielen und das Potenzial haben, in eine klinische Therapie \u00fcberf\u00fchrt zu werden.<\/p>\n\n\n\n<p>Die erste Frage, der wir nachgegangen sind war, ob die neurologische Dysfunktion nach dem Auftreten von Symptomen reversibel ist. Die Umkehrung von Ph\u00e4notypen bei symptom-behafteten erwachsenen M\u00e4usen wurde in einigen Modellen des monogene Verlusts von neurologischen Funktionen nachgewiesen, insbesondere dem Verlust von MeCP2 beim Rett-Syndrom. Dies deutet darauf hin, dass zumindest in einigen F\u00e4llen die Neuroanatomie sufficiently intakt bleiben kann, so dass die Korrektur der diesen St\u00f6rungen zugrunde liegenden molekularen Dysfunktion, eine gesunde Physiologie wiederherstellen kann.<\/p>\n\n\n\n<p>In Anbetracht der Tatsache, dass beim MECP2-Duplikation Syndrom keine Neurodegeneration (Zerst\u00f6rung der Nervenzellen im Gehirn) auftritt, vermuten wir, dass die Wiederherstellung normaler MeCP2-Spiegel bei erwachsenen M\u00e4usen mit MECP2-Duplikation die Korrektur ihres Ph\u00e4notyp erm\u00f6glichen w\u00fcrde.<\/p>\n\n\n\n<p>Durch die Erzeugung und Charakterisierung eines MECP2-\u00fcberexprimierenden Mausmodells zeigen wir hier, dass die Korrektur der MeCP2-Spiegel die Defizite im Verhalten, auf molekularer und elektrophysiologischer Ebene weitgehend umkehrt.<\/p>\n\n\n\n<p>Wir haben MeCP2 auch mithilfe einer Antisense-Oligonukleotid-Strategie (ASO) reduced, die ein gr\u00f6\u00dferes Umwandlungspotenzial besitzt.<\/p>\n\n\n\n<p>\u03a4\u03b1 antisense-Oligonukleotide \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03ac, \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 Nukleins\u00e4uren, \u03c4\u03b1 \u03bf\u03c0\u03bf\u03af\u03b1 selektiv mit der aus einem Ziel-Gen transkribierten Boten-RNA (mRNA) verbinden k\u00f6nnen und diese damit stumm schalten k\u00f6nnen. Sie wurden erfolgreich zur Korrektur von Defiziten in verschiedenen Mausmodellen eingesetzt.<\/p>\n\n\n\n<p>Wir stellen fest, dass die Antisense-Oligonukleotide eine weitgehende Wiederherstellung des Ph\u00e4notyps in symptomatischen, transgenen, erwachsenen M\u00e4usen mit MECP2-Duplikation implizieren und die MECP2-Spiegel in lymphoblastoiden Zellen von Patienten mit MECP2-Duplikation dosisabh\u00e4ngig korrigieren.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill\"><a class=\"wp-block-button__link has-white-color has-text-color has-background wp-element-button\" href=\"https:\/\/www.nature.com\/articles\/nature16159\" style=\"border-radius:10px;background-color:#f7a13f\">Publikation ansehen<\/a><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Prof. Huda Zoghbi et al. (Baylor College of Medicine, Texas, USA) ver\u00f6ffentlichen in der Zeitschrift Nature einen Artikel mit dem Titel \u00ab\u00a0Reversibler Ph\u00e4notyp bei M\u00e4usen durch die Verwendung von genetischer [&hellip;]<\/p>","protected":false},"author":1,"featured_media":6891,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[58],"tags":[],"class_list":["post-7363","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publikationen"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Reversibler Ph\u00e4notyp bei M\u00e4usen - DupMECP2<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dupmecp2.eu\/el\/\u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03b5\u03c6\u03cc\u03bc\u03b5\u03bd\u03bf\u03c2-\u03c6\u03b1\u03bd\u03bf\u03c4\u03cd\u03c0\u03bf\u03c2-\u03c3\u03b5-maeusen\/?lang=de\" \/>\n<meta property=\"og:locale\" content=\"el_GR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Reversibler Ph\u00e4notyp bei M\u00e4usen - DupMECP2\" \/>\n<meta property=\"og:description\" content=\"Prof. Huda Zoghbi et al. (Baylor College of Medicine, Texas, USA) ver\u00f6ffentlichen in der Zeitschrift Nature einen Artikel mit dem Titel \u00ab\u00a0Reversibler Ph\u00e4notyp bei M\u00e4usen durch die Verwendung von genetischer [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dupmecp2.eu\/el\/\u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03b5\u03c6\u03cc\u03bc\u03b5\u03bd\u03bf\u03c2-\u03c6\u03b1\u03bd\u03bf\u03c4\u03cd\u03c0\u03bf\u03c2-\u03c3\u03b5-maeusen\/?lang=de\" \/>\n<meta property=\"og:site_name\" content=\"DupMECP2\" \/>\n<meta property=\"article:published_time\" content=\"2022-06-14T18:42:45+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-11-13T13:19:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Zoghbi-2015.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"900\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Caroline\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"\u03a3\u03c5\u03bd\u03c4\u03ac\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc\" \/>\n\t<meta name=\"twitter:data1\" content=\"Caroline\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u0395\u03ba\u03c4\u03b9\u03bc\u03ce\u03bc\u03b5\u03bd\u03bf\u03c2 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 \u03bb\u03b5\u03c0\u03c4\u03ac\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de#article\",\"isPartOf\":{\"@id\":\"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de\"},\"author\":{\"name\":\"Caroline\",\"@id\":\"https:\/\/dupmecp2.eu\/#\/schema\/person\/b41e8cbba153cd974ee340386af279ee\"},\"headline\":\"Reversibler Ph\u00e4notyp bei M\u00e4usen\",\"datePublished\":\"2022-06-14T18:42:45+00:00\",\"dateModified\":\"2022-11-13T13:19:33+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de\"},\"wordCount\":452,\"publisher\":{\"@id\":\"https:\/\/dupmecp2.eu\/#organization\"},\"image\":{\"@id\":\"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Zoghbi-2015.jpg\",\"articleSection\":[\"Publikationen\"],\"inLanguage\":\"el\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de\",\"url\":\"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de\",\"name\":\"Reversibler Ph\u00e4notyp bei M\u00e4usen - DupMECP2\",\"isPartOf\":{\"@id\":\"https:\/\/dupmecp2.eu\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de#primaryimage\"},\"image\":{\"@id\":\"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Zoghbi-2015.jpg\",\"datePublished\":\"2022-06-14T18:42:45+00:00\",\"dateModified\":\"2022-11-13T13:19:33+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de#breadcrumb\"},\"inLanguage\":\"el\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"el\",\"@id\":\"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de#primaryimage\",\"url\":\"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Zoghbi-2015.jpg\",\"contentUrl\":\"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Zoghbi-2015.jpg\",\"width\":900,\"height\":600},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/dupmecp2.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publikationen\",\"item\":\"https:\/\/dupmecp2.eu\/category\/publikationen\/?lang=de\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Reversibler Ph\u00e4notyp bei M\u00e4usen\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/dupmecp2.eu\/#website\",\"url\":\"https:\/\/dupmecp2.eu\/\",\"name\":\"DupMECP2\",\"description\":\"EU\",\"publisher\":{\"@id\":\"https:\/\/dupmecp2.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/dupmecp2.eu\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"el\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/dupmecp2.eu\/#organization\",\"name\":\"DupMECP2\",\"url\":\"https:\/\/dupmecp2.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"el\",\"@id\":\"https:\/\/dupmecp2.eu\/#\/schema\/logo\/image\/\",\"url\":\"\",\"contentUrl\":\"\",\"caption\":\"DupMECP2\"},\"image\":{\"@id\":\"https:\/\/dupmecp2.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/dupmecp2.eu\/#\/schema\/person\/b41e8cbba153cd974ee340386af279ee\",\"name\":\"Caroline\",\"sameAs\":[\"https:\/\/dupmecp2.eu\"],\"url\":\"https:\/\/dupmecp2.eu\/el\/author\/417a2385dc37aa45\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u0391\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03b5\u03c0\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 Ph\u00e4notyp bei M\u00e4usen - DupMECP2","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/dupmecp2.eu\/el\/\u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03b5\u03c6\u03cc\u03bc\u03b5\u03bd\u03bf\u03c2-\u03c6\u03b1\u03bd\u03bf\u03c4\u03cd\u03c0\u03bf\u03c2-\u03c3\u03b5-maeusen\/?lang=de","og_locale":"el_GR","og_type":"article","og_title":"Reversibler Ph\u00e4notyp bei M\u00e4usen - DupMECP2","og_description":"Prof. Huda Zoghbi et al. (Baylor College of Medicine, Texas, USA) ver\u00f6ffentlichen in der Zeitschrift Nature einen Artikel mit dem Titel \u00ab\u00a0Reversibler Ph\u00e4notyp bei M\u00e4usen durch die Verwendung von genetischer [&hellip;]","og_url":"https:\/\/dupmecp2.eu\/el\/\u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03b5\u03c6\u03cc\u03bc\u03b5\u03bd\u03bf\u03c2-\u03c6\u03b1\u03bd\u03bf\u03c4\u03cd\u03c0\u03bf\u03c2-\u03c3\u03b5-maeusen\/?lang=de","og_site_name":"DupMECP2","article_published_time":"2022-06-14T18:42:45+00:00","article_modified_time":"2022-11-13T13:19:33+00:00","og_image":[{"width":900,"height":600,"url":"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Zoghbi-2015.jpg","type":"image\/jpeg"}],"author":"Caroline","twitter_card":"summary_large_image","twitter_misc":{"\u03a3\u03c5\u03bd\u03c4\u03ac\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc":"Caroline","\u0395\u03ba\u03c4\u03b9\u03bc\u03ce\u03bc\u03b5\u03bd\u03bf\u03c2 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c2 \u03b1\u03bd\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7\u03c2":"2 \u03bb\u03b5\u03c0\u03c4\u03ac"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de#article","isPartOf":{"@id":"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de"},"author":{"name":"Caroline","@id":"https:\/\/dupmecp2.eu\/#\/schema\/person\/b41e8cbba153cd974ee340386af279ee"},"headline":"Reversibler Ph\u00e4notyp bei M\u00e4usen","datePublished":"2022-06-14T18:42:45+00:00","dateModified":"2022-11-13T13:19:33+00:00","mainEntityOfPage":{"@id":"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de"},"wordCount":452,"publisher":{"@id":"https:\/\/dupmecp2.eu\/#organization"},"image":{"@id":"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de#primaryimage"},"thumbnailUrl":"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Zoghbi-2015.jpg","articleSection":["Publikationen"],"inLanguage":"el"},{"@type":"WebPage","@id":"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de","url":"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de","name":"\u0391\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03b5\u03c0\u03c4\u03b9\u03ba\u03cc \u03c3\u03cd\u03c3\u03c4\u03b7\u03bc\u03b1 Ph\u00e4notyp bei M\u00e4usen - DupMECP2","isPartOf":{"@id":"https:\/\/dupmecp2.eu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de#primaryimage"},"image":{"@id":"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de#primaryimage"},"thumbnailUrl":"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Zoghbi-2015.jpg","datePublished":"2022-06-14T18:42:45+00:00","dateModified":"2022-11-13T13:19:33+00:00","breadcrumb":{"@id":"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de#breadcrumb"},"inLanguage":"el","potentialAction":[{"@type":"ReadAction","target":["https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de"]}]},{"@type":"ImageObject","inLanguage":"el","@id":"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de#primaryimage","url":"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Zoghbi-2015.jpg","contentUrl":"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Zoghbi-2015.jpg","width":900,"height":600},{"@type":"BreadcrumbList","@id":"https:\/\/dupmecp2.eu\/reversibler-phaenotyp-bei-maeusen\/?lang=de#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/dupmecp2.eu\/"},{"@type":"ListItem","position":2,"name":"Publikationen","item":"https:\/\/dupmecp2.eu\/category\/publikationen\/?lang=de"},{"@type":"ListItem","position":3,"name":"Reversibler Ph\u00e4notyp bei M\u00e4usen"}]},{"@type":"WebSite","@id":"https:\/\/dupmecp2.eu\/#website","url":"https:\/\/dupmecp2.eu\/","name":"DupMECP2","description":"\u0395\u0395","publisher":{"@id":"https:\/\/dupmecp2.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/dupmecp2.eu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"el"},{"@type":"Organization","@id":"https:\/\/dupmecp2.eu\/#organization","name":"DupMECP2","url":"https:\/\/dupmecp2.eu\/","logo":{"@type":"ImageObject","inLanguage":"el","@id":"https:\/\/dupmecp2.eu\/#\/schema\/logo\/image\/","url":"","contentUrl":"","caption":"DupMECP2"},"image":{"@id":"https:\/\/dupmecp2.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/dupmecp2.eu\/#\/schema\/person\/b41e8cbba153cd974ee340386af279ee","name":"\u039a\u03b1\u03c1\u03bf\u03bb\u03af\u03bd\u03b1","sameAs":["https:\/\/dupmecp2.eu"],"url":"https:\/\/dupmecp2.eu\/el\/author\/417a2385dc37aa45\/"}]}},"_links":{"self":[{"href":"https:\/\/dupmecp2.eu\/el\/wp-json\/wp\/v2\/posts\/7363","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dupmecp2.eu\/el\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dupmecp2.eu\/el\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dupmecp2.eu\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dupmecp2.eu\/el\/wp-json\/wp\/v2\/comments?post=7363"}],"version-history":[{"count":0,"href":"https:\/\/dupmecp2.eu\/el\/wp-json\/wp\/v2\/posts\/7363\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dupmecp2.eu\/el\/wp-json\/wp\/v2\/media\/6891"}],"wp:attachment":[{"href":"https:\/\/dupmecp2.eu\/el\/wp-json\/wp\/v2\/media?parent=7363"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dupmecp2.eu\/el\/wp-json\/wp\/v2\/categories?post=7363"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dupmecp2.eu\/el\/wp-json\/wp\/v2\/tags?post=7363"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}