{"id":9394,"date":"2022-06-14T20:42:45","date_gmt":"2022-06-14T18:42:45","guid":{"rendered":"https:\/\/dupmecp2.eu\/reversal-of-phenotypes-in-mecp2-duplication-mice\/"},"modified":"2024-11-04T21:53:13","modified_gmt":"2024-11-04T20:53:13","slug":"%ce%b1%ce%bd%cf%84%ce%b9%cf%83%cf%84%cf%81%ce%bf%cf%86%ce%ae-%cf%84%cf%89%ce%bd-%cf%86%ce%b1%ce%b9%ce%bd%ce%bf%cf%84%cf%8d%cf%80%cf%89%ce%bd-%cf%83%ce%b5-%cf%80%ce%bf%ce%bd%cf%84%ce%af%ce%ba%ce%b9","status":"publish","type":"post","link":"https:\/\/dupmecp2.eu\/el\/%ce%b1%ce%bd%cf%84%ce%b9%cf%83%cf%84%cf%81%ce%bf%cf%86%ce%ae-%cf%84%cf%89%ce%bd-%cf%86%ce%b1%ce%b9%ce%bd%ce%bf%cf%84%cf%8d%cf%80%cf%89%ce%bd-%cf%83%ce%b5-%cf%80%ce%bf%ce%bd%cf%84%ce%af%ce%ba%ce%b9\/","title":{"rendered":"\u0391\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03c9\u03bd \u03c6\u03b1\u03b9\u03bd\u03bf\u03c4\u03cd\u03c0\u03c9\u03bd \u03c3\u03b5 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03bc\u03b5 \u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 MECP2"},"content":{"rendered":"<p><strong>\u039f \u03ba\u03b1\u03b8\u03b7\u03b3\u03b7\u03c4\u03ae\u03c2 Huda Zoghbi \u03ba.\u03ac. (Baylor College of Medicine, \u03a4\u03ad\u03be\u03b1\u03c2, \u0397\u03a0\u0391) \u03b4\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b1\u03bd \u03ac\u03c1\u03b8\u03c1\u03bf \u03c3\u03c4\u03bf \u03c0\u03b5\u03c1\u03b9\u03bf\u03b4\u03b9\u03ba\u03cc Nature \u03bc\u03b5 \u03c4\u03af\u03c4\u03bb\u03bf \"Reversible phenotype in mice using gene rescue or antisense oligonucleotides\". \u03a3\u03c4\u03bf \u03ac\u03c1\u03b8\u03c1\u03bf \u03b1\u03c5\u03c4\u03cc \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03c7\u03c1\u03ae\u03c3\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03b7\u03bc\u03b5\u03b9\u03c9\u03c4\u03b9\u03ba\u03ce\u03bd \u03bf\u03bb\u03b9\u03b3\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03b9\u03b4\u03af\u03c9\u03bd \u03c3\u03c4\u03b7 \u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03bf\u03c5 MeCP2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03b9\u03ba\u03ce\u03bd, \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ce\u03bd \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03b6\u03c9\u03b9\u03ba\u03cc \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf \u03bc\u03b5 \u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 MECP2.<\/strong><\/p>\n\n\n\n<p>\u0391\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae \u03c4\u03c9\u03bd \u03c6\u03b1\u03b9\u03bd\u03bf\u03c4\u03cd\u03c0\u03c9\u03bd \u03c3\u03b5 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03bc\u03b5 \u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 MECP2 \u03bc\u03b5 \u03c4\u03b7 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b4\u03b9\u03ac\u03c3\u03c9\u03c3\u03b7\u03c2 \u03ae \u03b1\u03bd\u03c4\u03b9\u03c3\u03b7\u03bc\u03b9\u03ba\u03ce\u03bd \u03bf\u03bb\u03b9\u03b3\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03b9\u03b4\u03af\u03c9\u03bd, Huda Zoghbi <em>et al,<\/em> <em>\u03a6\u03cd\u03c3\u03b7<\/em><strong> 528, <\/strong>123-126 (2015)<\/p>\n\n\n\n<p><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>\u03a0\u0395\u03a1\u038a\u039b\u0397\u03a8\u0397 \u0394\u0397\u039c\u039f\u03a3\u038a\u0395\u03a5\u03a3\u0397\u03a3:<\/strong><\/p>\n\n\n\n<p>\u039f\u03b9 \u03c0\u03b1\u03c1\u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03b1\u03c1\u03b9\u03b8\u03bc\u03bf\u03cd 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\u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03c1\u03cc\u03c9\u03c1\u03bf \u03b8\u03ac\u03bd\u03b1\u03c4\u03bf.<\/p>\n\n\n\n<p>\u03a4\u03bf \u03b5\u03c5\u03c1\u03cd \u03c6\u03ac\u03c3\u03bc\u03b1 \u03c4\u03c9\u03bd \u03b5\u03bb\u03bb\u03b5\u03b9\u03bc\u03bc\u03ac\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c5\u03c0\u03b5\u03c1\u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03b8\u03c5\u03bb\u03bf-CpG-\u03b4\u03b5\u03c3\u03bc\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 2 (MeCP2) \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03af \u03c4\u03c1\u03bf\u03bc\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03cc\u03ba\u03bb\u03b7\u03c3\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03c0\u03b1\u03c1\u03b1\u03b4\u03bf\u03c3\u03b9\u03b1\u03ba\u03ad\u03c2 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\u03c4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2, \u03b7 \u03bd\u03b5\u03c5\u03c1\u03bf\u03b1\u03bd\u03b1\u03c4\u03bf\u03bc\u03af\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03bc\u03b5\u03af\u03bd\u03b5\u03b9 \u03b5\u03c0\u03b1\u03c1\u03ba\u03ce\u03c2 \u03ac\u03b8\u03b9\u03ba\u03c4\u03b7, \u03ce\u03c3\u03c4\u03b5 \u03b7 \u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03b4\u03c5\u03c3\u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03ad\u03c0\u03b5\u03b9 \u03b1\u03c5\u03c4\u03ad\u03c2 \u03c4\u03b9\u03c2 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ad\u03c2 \u03bd\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ae\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c5\u03b3\u03b9\u03ae \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03af\u03b1.<\/p>\n\n\n\n<p>\u0394\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03c0\u03bf\u03c5\u03c3\u03af\u03b1\u03c2 \u03bd\u03b5\u03c5\u03c1\u03bf\u03b5\u03ba\u03c6\u03c5\u03bb\u03b9\u03c3\u03bc\u03bf\u03cd \u03c3\u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03bf\u03cd \u03c4\u03bf\u03c5 MECP2, \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03bf\u03c5\u03bc\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03b1\u03c0\u03bf\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd MeCP2 \u03c3\u03c4\u03b1 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b1 \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03bc\u03b5 \u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 MECP2 \u03b8\u03b1 \u03b4\u03b9\u03b1\u03c3\u03ce\u03c3\u03b5\u03b9 \u03c4\u03bf\u03bd \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03c5\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2.<\/p>\n\n\n\n<p>\u0394\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ad\u03bd\u03b1 \u03c5\u03c0\u03cc \u03cc\u03c1\u03bf\u03c5\u03c2 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03bf \u03c0\u03bf\u03bd\u03c4\u03b9\u03ba\u03bf\u03cd \u03bc\u03b5 \u03c5\u03c0\u03b5\u03c1\u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 Mecp2, \u03b5\u03b4\u03ce \u03b4\u03b5\u03af\u03c7\u03bd\u03bf\u03c5\u03bc\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03b5\u03c0\u03b9\u03c0\u03ad\u03b4\u03c9\u03bd \u03c4\u03bf\u03c5 MeCP2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03ad\u03c6\u03b5\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03c6\u03bf\u03c1\u03b9\u03ba\u03ac, \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ac \u03ba\u03b1\u03b9 \u03b7\u03bb\u03b5\u03ba\u03c4\u03c1\u03bf\u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b5\u03bb\u03bb\u03b5\u03af\u03bc\u03bc\u03b1\u03c4\u03b1.<\/p>\n\n\n\n<p>\u039c\u03b5\u03b9\u03ce\u03c3\u03b1\u03bc\u03b5 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c4\u03bf MeCP2 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03ce\u03bd\u03c4\u03b1\u03c2 \u03bc\u03b9\u03b1 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9-\u03bf\u03bb\u03b9\u03b3\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03b9\u03b4\u03af\u03c9\u03bd, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03bc\u03b5\u03c4\u03b1\u03c6\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03cc.<\/p>\n\n\n\n<p>\u03a4\u03b1 antisense \u03bf\u03bb\u03b9\u03b3\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03ba\u03c1\u03ac, \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b1 \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03ca\u03ba\u03ac \u03bf\u03be\u03ad\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03b5\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u03bd\u03b1 \u03c5\u03b2\u03c1\u03b9\u03b4\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03bf\u03cd\u03bd \u03bc\u03b5 \u03c4\u03bf \u03b1\u03b3\u03b3\u03b5\u03bb\u03b9\u03bf\u03c6\u03cc\u03c1\u03bf RNA \u03c0\u03bf\u03c5 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03ac\u03c6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03ad\u03bd\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf-\u03c3\u03c4\u03cc\u03c7\u03bf \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03c4\u03bf \u03c3\u03b9\u03c9\u03c0\u03ae\u03c3\u03bf\u03c5\u03bd, \u03ba\u03b1\u03b9 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03b8\u03b5\u03af \u03bc\u03b5 \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7 \u03b5\u03bb\u03bb\u03b5\u03b9\u03bc\u03bc\u03ac\u03c4\u03c9\u03bd \u03c3\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b1 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03c0\u03bf\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd.<\/p>\n\n\n\n<p>\u0394\u03b9\u03b1\u03c0\u03b9\u03c3\u03c4\u03ce\u03bd\u03bf\u03c5\u03bc\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03b1\u03bd\u03c4\u03b9\u03c3\u03b7\u03bc\u03b5\u03b9\u03c9\u03c4\u03b9\u03ba\u03cc \u03bf\u03bb\u03b9\u03b3\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03bf \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03b5\u03af \u03b5\u03c5\u03c1\u03b5\u03af\u03b1 \u03c6\u03b1\u03b9\u03bd\u03bf\u03c4\u03c5\u03c0\u03b9\u03ba\u03ae \u03b4\u03b9\u03ac\u03c3\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac \u03b4\u03b9\u03b1\u03b3\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ac \u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\u03b1 \u03bc\u03b5 \u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 MECP2 (MECP2-TG) \u03ba\u03b1\u03b9 \u03b4\u03b9\u03bf\u03c1\u03b8\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03bf\u03c5 MECP2 \u03c3\u03b5 \u03bb\u03b5\u03bc\u03c6\u03bf\u03b2\u03bb\u03b1\u03c3\u03c4\u03bf\u03b5\u03b9\u03b4\u03ae \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c0\u03cc \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 MECP2 \u03bc\u03b5 \u03b4\u03bf\u03c3\u03bf\u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bc\u03b5\u03bd\u03bf \u03c4\u03c1\u03cc\u03c0\u03bf.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill\"><a class=\"wp-block-button__link has-white-color has-text-color has-background wp-element-button\" href=\"https:\/\/www.nature.com\/articles\/nature16159\" style=\"border-radius:14px;background-color:#f7a13f\" target=\"_blank\" rel=\"noreferrer noopener\">\u03a3\u03c4\u03b7 \u03b4\u03b7\u03bc\u03bf\u03c3\u03af\u03b5\u03c5\u03c3\u03b7<\/a><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Prof. Huda Zoghbi et al (Baylor College of Medicine, Texas, USA) published an article in the journal Nature entitled \u00ab\u00a0Reversible phenotype in mice using gene rescue or antisense oligonucleotides\u00a0\u00bb. This [&hellip;]<\/p>","protected":false},"author":1,"featured_media":4838,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[88],"tags":[],"class_list":["post-9394","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publications-en"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Reversal of phenotypes in MECP2 duplication mice - DupMECP2<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dupmecp2.eu\/el\/\u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03c1\u03bf\u03c6\u03ae-\u03c4\u03c9\u03bd-\u03c6\u03b1\u03b9\u03bd\u03bf\u03c4\u03cd\u03c0\u03c9\u03bd-\u03c3\u03b5-\u03c0\u03bf\u03bd\u03c4\u03af\u03ba\u03b9\/\" \/>\n<meta property=\"og:locale\" content=\"el_GR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Reversal of phenotypes in MECP2 duplication mice - DupMECP2\" \/>\n<meta property=\"og:description\" content=\"Prof. Huda Zoghbi et al (Baylor College of Medicine, Texas, USA) published an article in the journal Nature entitled \u00ab\u00a0Reversible phenotype in mice using gene rescue or antisense oligonucleotides\u00a0\u00bb. 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