{"id":15973,"date":"2022-06-14T20:42:45","date_gmt":"2022-06-14T20:42:45","guid":{"rendered":"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/"},"modified":"2023-04-17T16:11:06","modified_gmt":"2023-04-17T16:11:06","slug":"fenotipo-reversibile-in-un-modello-di-topo-umanizzato","status":"publish","type":"post","link":"https:\/\/dupmecp2.eu\/pl\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/","title":{"rendered":"Fenotipo reversibile in un modello di topo umanizzato"},"content":{"rendered":"<p class=\"wp-block-paragraph\"><strong>Shao i jego wsp\u00f3\u0142pracownicy z grupy prof. Zoghbi z Baylor College of Medicine w Teksasie (USA) opublikowali artyku\u0142 w czasopi\u015bmie Science Translational Medicine zatytu\u0142owany \"Terapia z u\u017cyciem oligonukleotyd\u00f3w antisenso w modelu topo umanizzato z Sindrome da Duplicazione di MECP2\". <\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Ka\u017cdy gatunek ma sw\u00f3j w\u0142asny genom. Geny koduj\u0105 bia\u0142ka, kt\u00f3re s\u0105 typowe dla ka\u017cdego gatunku. Mo\u017cliwe jest, \u017ce bia\u0142ka ludzkie lub topo s\u0105 bardziej zr\u00f3\u017cnicowane. Model zastosowany w tym artykule, zwany \"modelem umanizzato\", umo\u017cliwia lepsz\u0105 ocen\u0119 aktywno\u015bci oligonukleotyd\u00f3w antysensownych, zw\u0142aszcza w odniesieniu do bia\u0142ek ludzkich wytwarzanych przez topo. E' quindi piu' vicino all'uso futuro di oligonucleotidi antisenso nell'uomo.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Niniejszy artyku\u0142 przedstawia wyniki uzyskane podczas iniekcji wewn\u0105trzkomorowej oligonukleotyd\u00f3w antysensownych w tym modelu topo z \"MECP2 umanizzato\", w kt\u00f3rym topo zawiera due allele umani di MECP2 i \u017cadnego allelu endogennego.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Soministrazione zmniejszy\u0142o ekspresj\u0119 MeCP2 w szyjce macicy, \u0142agodz\u0105c deficyty zachowa\u0144 i poprawiaj\u0105c ekspresj\u0119 wszystkich gen\u00f3w, kt\u00f3re mog\u0105 by\u0107 regulowane.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Terapia oligonukleotydami antysensownymi w humanizowanym mysim modelu zespo\u0142u duplikacji MECP2, Shao i in.<em>Sci. Transl. Med<\/em>. <strong>13<\/strong>, 7785 (2021)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>RIASSUNTO DELL'ARTICOLO:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Wiele przypadk\u00f3w niepe\u0142nosprawno\u015bci intelektualnej jest spowodowanych zmienn\u0105 liczb\u0105 kopii genu i obecnie nie ma przetestowanych opcji leczenia dla tej klasy chor\u00f3b. La Sindrome da Duplicazione di MECP2 (MDS) jest jednym z najcz\u0119stszych zaburze\u0144 genomu w maschi i wynika z duplikacji genu koduj\u0105cego bia\u0142ko MECP2. W przesz\u0142o\u015bci wykazano, \u017ce terapia oligonukleotydami antysensownymi (ASO) mo\u017ce zwi\u0119kszy\u0107 ilo\u015b\u0107 bia\u0142ka MeCP2 w topi modello i odwr\u00f3ci\u0107 manifestacj\u0119 objaw\u00f3w.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Questo modello di topo porta un allele umano transgenico e un allele di topo, con quest'ultimo protetto dall'azione dell'oligonucleotide antisenso MECP2 specifico. Poniewa\u017c st\u0119\u017cenie bia\u0142ka MeCP2 jest bardzo wa\u017cnym parametrem, ilo\u015b\u0107 oligonukleotyd\u00f3w antysensownych musi by\u0107 dozowana w taki spos\u00f3b, aby ilo\u015b\u0107 MeCP2 nie zmniejszy\u0142a si\u0119 zbytnio, powoduj\u0105c w ten spos\u00f3b zesp\u00f3\u0142 Retta. Z tego powodu wygenerowali\u015bmy model topo z \"MECP2 umanizzato\", kt\u00f3ry przenosi dwa ludzkie allele MECP2 i nie ma endogennych alleli topo. Podanie wewn\u0105trzkomorowe oligonukleotydu antisenso skutecznie zmniejsza ilo\u015b\u0107 bia\u0142ka MECP2 wytwarzanego w szyjce macicy topo. Ponadto, terapia ta jest w stanie z\u0142agodzi\u0107 r\u00f3\u017cne deficyty behawioralne i przywr\u00f3ci\u0107 ekspresj\u0119 niekt\u00f3rych gen\u00f3w regulatorowych MeCP2 w spos\u00f3b zale\u017cny od ich dawki i bez \u017cadnej toksyczno\u015bci. La somministrazione di oligonucleotidi antisenso a livello del sistema nervoso centrale e' quindi ben tollerata e benefica nel modello di topo e fornisce un approccio che potrebbe anche avere successo per la cura della Sindrome da Duplicazione di MECP2 nell'uomo.<\/p>\n\n\n\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button is-style-fill\"><a class=\"wp-block-button__link has-background wp-element-button\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33658357\/\" style=\"border-radius:14px;background-color:#f7a13f\" target=\"_blank\" rel=\"noreferrer noopener\">Alla pubblicazione<\/a><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Shao e i suoi collaboratori del gruppo del Prof.ssa Zoghbi al Baylor College of Medicine in Texas, USA hanno pubblicato un articolo sulla rivista Science Translational Medicine intitolato \u201cTerapia con [&hellip;]<\/p>","protected":false},"author":1,"featured_media":13607,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[139],"tags":[],"class_list":["post-15973","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pubblicazioni"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Fenotipo reversibile in un modello di topo umanizzato - DupMECP2<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/dupmecp2.eu\/pl\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it\" \/>\n<meta property=\"og:locale\" content=\"pl_PL\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fenotipo reversibile in un modello di topo umanizzato - DupMECP2\" \/>\n<meta property=\"og:description\" content=\"Shao e i suoi collaboratori del gruppo del Prof.ssa Zoghbi al Baylor College of Medicine in Texas, USA hanno pubblicato un articolo sulla rivista Science Translational Medicine intitolato \u201cTerapia con [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/dupmecp2.eu\/pl\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it\" \/>\n<meta property=\"og:site_name\" content=\"DupMECP2\" \/>\n<meta property=\"article:published_time\" content=\"2022-06-14T20:42:45+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-04-17T16:11:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Publication-Zoghbi-Souris-Humanisees.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1500\" \/>\n\t<meta property=\"og:image:height\" content=\"1050\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Caroline\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Napisane przez\" \/>\n\t<meta name=\"twitter:data1\" content=\"Caroline\" \/>\n\t<meta name=\"twitter:label2\" content=\"Szacowany czas czytania\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuty\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it#article\",\"isPartOf\":{\"@id\":\"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it\"},\"author\":{\"name\":\"Caroline\",\"@id\":\"https:\/\/dupmecp2.eu\/#\/schema\/person\/b41e8cbba153cd974ee340386af279ee\"},\"headline\":\"Fenotipo reversibile in un modello di topo umanizzato\",\"datePublished\":\"2022-06-14T20:42:45+00:00\",\"dateModified\":\"2023-04-17T16:11:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it\"},\"wordCount\":470,\"publisher\":{\"@id\":\"https:\/\/dupmecp2.eu\/#organization\"},\"image\":{\"@id\":\"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Publication-Zoghbi-Souris-Humanisees.jpg\",\"articleSection\":[\"Pubblicazioni\"],\"inLanguage\":\"pl-PL\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it\",\"url\":\"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it\",\"name\":\"Fenotipo reversibile in un modello di topo umanizzato - DupMECP2\",\"isPartOf\":{\"@id\":\"https:\/\/dupmecp2.eu\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it#primaryimage\"},\"image\":{\"@id\":\"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it#primaryimage\"},\"thumbnailUrl\":\"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Publication-Zoghbi-Souris-Humanisees.jpg\",\"datePublished\":\"2022-06-14T20:42:45+00:00\",\"dateModified\":\"2023-04-17T16:11:06+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it#breadcrumb\"},\"inLanguage\":\"pl-PL\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"pl-PL\",\"@id\":\"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it#primaryimage\",\"url\":\"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Publication-Zoghbi-Souris-Humanisees.jpg\",\"contentUrl\":\"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Publication-Zoghbi-Souris-Humanisees.jpg\",\"width\":1500,\"height\":1050},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/dupmecp2.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Pubblicazioni\",\"item\":\"https:\/\/dupmecp2.eu\/category\/pubblicazioni\/?lang=it\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Fenotipo reversibile in un modello di topo umanizzato\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/dupmecp2.eu\/#website\",\"url\":\"https:\/\/dupmecp2.eu\/\",\"name\":\"DupMECP2\",\"description\":\"EU\",\"publisher\":{\"@id\":\"https:\/\/dupmecp2.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/dupmecp2.eu\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"pl-PL\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/dupmecp2.eu\/#organization\",\"name\":\"DupMECP2\",\"url\":\"https:\/\/dupmecp2.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"pl-PL\",\"@id\":\"https:\/\/dupmecp2.eu\/#\/schema\/logo\/image\/\",\"url\":\"\",\"contentUrl\":\"\",\"caption\":\"DupMECP2\"},\"image\":{\"@id\":\"https:\/\/dupmecp2.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/dupmecp2.eu\/#\/schema\/person\/b41e8cbba153cd974ee340386af279ee\",\"name\":\"Caroline\",\"sameAs\":[\"https:\/\/dupmecp2.eu\"],\"url\":\"https:\/\/dupmecp2.eu\/pl\/author\/417a2385dc37aa45\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Fenotipo reversibile in un modello di topo umanizzato - DupMECP2","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/dupmecp2.eu\/pl\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it","og_locale":"pl_PL","og_type":"article","og_title":"Fenotipo reversibile in un modello di topo umanizzato - DupMECP2","og_description":"Shao e i suoi collaboratori del gruppo del Prof.ssa Zoghbi al Baylor College of Medicine in Texas, USA hanno pubblicato un articolo sulla rivista Science Translational Medicine intitolato \u201cTerapia con [&hellip;]","og_url":"https:\/\/dupmecp2.eu\/pl\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it","og_site_name":"DupMECP2","article_published_time":"2022-06-14T20:42:45+00:00","article_modified_time":"2023-04-17T16:11:06+00:00","og_image":[{"width":1500,"height":1050,"url":"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Publication-Zoghbi-Souris-Humanisees.jpg","type":"image\/jpeg"}],"author":"Caroline","twitter_card":"summary_large_image","twitter_misc":{"Napisane przez":"Caroline","Szacowany czas czytania":"2 minuty"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it#article","isPartOf":{"@id":"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it"},"author":{"name":"Caroline","@id":"https:\/\/dupmecp2.eu\/#\/schema\/person\/b41e8cbba153cd974ee340386af279ee"},"headline":"Fenotipo reversibile in un modello di topo umanizzato","datePublished":"2022-06-14T20:42:45+00:00","dateModified":"2023-04-17T16:11:06+00:00","mainEntityOfPage":{"@id":"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it"},"wordCount":470,"publisher":{"@id":"https:\/\/dupmecp2.eu\/#organization"},"image":{"@id":"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it#primaryimage"},"thumbnailUrl":"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Publication-Zoghbi-Souris-Humanisees.jpg","articleSection":["Pubblicazioni"],"inLanguage":"pl-PL"},{"@type":"WebPage","@id":"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it","url":"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it","name":"Fenotipo reversibile in un modello di topo umanizzato - DupMECP2","isPartOf":{"@id":"https:\/\/dupmecp2.eu\/#website"},"primaryImageOfPage":{"@id":"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it#primaryimage"},"image":{"@id":"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it#primaryimage"},"thumbnailUrl":"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Publication-Zoghbi-Souris-Humanisees.jpg","datePublished":"2022-06-14T20:42:45+00:00","dateModified":"2023-04-17T16:11:06+00:00","breadcrumb":{"@id":"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it#breadcrumb"},"inLanguage":"pl-PL","potentialAction":[{"@type":"ReadAction","target":["https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it"]}]},{"@type":"ImageObject","inLanguage":"pl-PL","@id":"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it#primaryimage","url":"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Publication-Zoghbi-Souris-Humanisees.jpg","contentUrl":"https:\/\/dupmecp2.eu\/wp-content\/uploads\/2022\/06\/Publication-Zoghbi-Souris-Humanisees.jpg","width":1500,"height":1050},{"@type":"BreadcrumbList","@id":"https:\/\/dupmecp2.eu\/fenotipo-reversibile-in-un-modello-di-topo-umanizzato\/?lang=it#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/dupmecp2.eu\/"},{"@type":"ListItem","position":2,"name":"Pubblicazioni","item":"https:\/\/dupmecp2.eu\/category\/pubblicazioni\/?lang=it"},{"@type":"ListItem","position":3,"name":"Fenotipo reversibile in un modello di topo umanizzato"}]},{"@type":"WebSite","@id":"https:\/\/dupmecp2.eu\/#website","url":"https:\/\/dupmecp2.eu\/","name":"DupMECP2","description":"UE","publisher":{"@id":"https:\/\/dupmecp2.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/dupmecp2.eu\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"pl-PL"},{"@type":"Organization","@id":"https:\/\/dupmecp2.eu\/#organization","name":"DupMECP2","url":"https:\/\/dupmecp2.eu\/","logo":{"@type":"ImageObject","inLanguage":"pl-PL","@id":"https:\/\/dupmecp2.eu\/#\/schema\/logo\/image\/","url":"","contentUrl":"","caption":"DupMECP2"},"image":{"@id":"https:\/\/dupmecp2.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/dupmecp2.eu\/#\/schema\/person\/b41e8cbba153cd974ee340386af279ee","name":"Caroline","sameAs":["https:\/\/dupmecp2.eu"],"url":"https:\/\/dupmecp2.eu\/pl\/author\/417a2385dc37aa45\/"}]}},"_links":{"self":[{"href":"https:\/\/dupmecp2.eu\/pl\/wp-json\/wp\/v2\/posts\/15973","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dupmecp2.eu\/pl\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dupmecp2.eu\/pl\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dupmecp2.eu\/pl\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dupmecp2.eu\/pl\/wp-json\/wp\/v2\/comments?post=15973"}],"version-history":[{"count":0,"href":"https:\/\/dupmecp2.eu\/pl\/wp-json\/wp\/v2\/posts\/15973\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dupmecp2.eu\/pl\/wp-json\/wp\/v2\/media\/13607"}],"wp:attachment":[{"href":"https:\/\/dupmecp2.eu\/pl\/wp-json\/wp\/v2\/media?parent=15973"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dupmecp2.eu\/pl\/wp-json\/wp\/v2\/categories?post=15973"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dupmecp2.eu\/pl\/wp-json\/wp\/v2\/tags?post=15973"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}